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Colorectal Cancer: 5 Things You Need to Know

Private: Jeffrey Meyerhardt, MD
Contributor Jeffrey Meyerhardt, MD
Private: Jessica Allegretti, MD, MPH
Contributor Jessica Allegretti, MD, MPH

Colorectal cancer is the third most common cancer in the U.S., but thanks to increased awareness about screenings, the death rate from colorectal cancer has been dropping for more than 20 years.

“For the most part, colorectal cancer is a curable and preventable disease,” says Dr. Jeffrey Meyerhardt, clinical director of the Gastrointestinal Cancer Treatment Center at Dana-Farber/Brigham and Women’s Cancer Center. “It is a cancer where we have very good data that shows screening prevents disease and saves lives.”

Below are answers to some key questions about the disease:

1. What are the risk factors for colorectal cancer?

Age and gender can increase the chance of developing colorectal cancer. Other risk factors include:

  • A family history of colon or rectal cancer
  • A personal history of cancer in the colon, rectum, ovary, endometrium, or breast
  • A history of polyps (small pieces of bulging tissue) in the colon or rectum
  • A history of ulcerative colitis or Crohn’s disease
  • Certain hereditary conditions, such as familial adenomatous polyposis and hereditary nonpolyposis colon cancer.
  • Obesity
  • Sedentary lifestyle
  • Certain dietary factors, including high intake of red and processed meat

2. How do doctors screen for colorectal cancer?

Aside from a physical exam to check general signs of health, other screening options include a fecal occult blood test, a double contrast Barium enema (lower GI series), a sigmoidoscopy, a colonoscopy or a virtual colonoscopy (colonography or CT colonography).

3. How often should you be screened?

Risk factors and health history will determine how often you should be screened for colorectal cancer and at what age you should start screening. For most patients, screening is recommended to start at age 50. However, if you have a family history or other risk factors for colorectal cancer, you should discuss with your doctor whether you should start screening earlier.

The frequency of the screening will depend on which test was used to screen, what was found, and your risk factors for colorectal cancer. It is important to know that these screening guidelines refer to patients with no concerning signs or symptoms. If you are having blood in your stool, for example, you should consult with your doctor.

4. What are the symptoms of colorectal cancer?

One of the most common signs of colorectal cancer includes a change in bowel habits or blood in the stool. Others include:

  • Diarrhea, constipation, or feeling that the bowel does not empty completely
  • Stools that are narrower than usual
  • Frequent gas pains, bloating, fullness, or cramps
  • Weight loss for no known reason
  • Persistent tiredness
  • Vomiting

5. How is colorectal cancer treated?

Surgery to remove the cancer is the most common treatment for all stages of colorectal cancer. There are several different types of surgery that can be performed depending on the cancer stage and location. If surgery is not sufficient, a doctor may also decide to use chemotherapy and/or radiation therapy.

There are also several targeted therapy options for colorectal cancer, including treatment with monoclonal antibodies.

Patients may also want to consider enrolling in a clinical trial for colorectal cancer. Dana-Farber currently has several trials open for colorectal cancer patients and the National Cancer Institute maintains a list of clinical trials at

This post originally appeared on Insight, the blog of Dana-Farber Cancer Institute.

Jessica Allegretti, MD, MPH, a Gastroenterologist in the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital, describes colon cancer screening guidelines and what to expect during a colonoscopy.

Private: Jeffrey Meyerhardt, MD
Jeffrey Meyerhardt, MD

Jeffrey Meyerhardt, MD, is the Clinical Director of the Gastrointestinal Cancer Treatment Center at Dana-Farber/Brigham and Women’s Cancer Center.

Private: Jessica Allegretti, MD, MPH
Jessica Allegretti, MD, MPH

Jessica Allegretti, MD, MPH, is a Gastroenterologist in the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital (BWH).

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